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Address for correspondance:
Laboratory of Skin Biology and Experimental Dermatology
Department of Dermatology (802)
University Medical School Nijmegen
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
Phone: +31.24.3613724
Fax: +31.24.3541184
E-mail: d.deheus@derma.umcn.nl

Visiting address and address for FedEx/DHl shipments:
Rene Descartesdreef 1
6525 GL Nijmegen
The Netherlands
Breakng News!!!!!! up

Breaking news 3-12-2007: Innate immunity and psoriasis

In Nature Genetics our group reports that individuals carrying extra copies of a cluster of genes encoding a family of small antimicrobial proteins are at increased risk of developing psoriasis. Psoriasis is a common inflammatory skin disease affecting up to 2% of the population.

Recente ontwikkelingen: een nieuwe genetische oorzaak voor psoriasis gevonden
Menselijke huidcellen verdedigen zich tegen micro-organismen met zelfgemaakte antibiotica, de zogeheten defensines. Ons laboratorium heeft samen met Britse en Duitse onderzoekers ontdekt dat deze defensines ook betrokken zijn bij de huidziekte psoriasis. Door genetische variaties maken sommige mensen heel veel defensines aan. Die extra defensines geven niet alleen een betere bescherming tegen infecties, maar maken mensen ook gevoeliger voor psoriasis. De ontdekking is gepubliceerd in Nature Genetics.

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